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Headache Medicine Connections


Headache Medicine Connections

Year: 2021, Volume: 1, Issue: 2, Pages: 33-36

Case Report

Transient Hypnic Headache-like Phenomenon in Guillain-Barre Syndrome: Lessons from a First Case Report

Received Date:11 November 2021, Accepted Date:19 December 2021, Published Date:24 December 2021


Headache is an uncommon feature of Guillain-Barre syndrome (GBS), which is more frequently associated with severe limb and/or back pain. However, when it does it occur, headache in GBS may emanate from a range of causes, including raised intracranial pressure, reversible cerebral vasoconstriction syndrome, posterior reversible encephalopathy syndrome, or due to complications of intravenous immunoglobulin (IVIg) therapy, such as aseptic meningitis and cerebral venous sinus thrombosis. Hypnic headache (HH)-like phenomenon has not been thus far described in association with GBS. We report herein a patient with GBS who developed HH-like phenomenon during the recovery phase; she developed a cyclical nocturnal headache lasting around four hours and demonstrated exquisite response to caffeine. We postulate potential mechanisms for the same.

Keywords: Hypnic headache, reversible cerebral vasoconstriction syndrome, posterior reversible encephalopathy syndrome, IVIg


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© 2021 Published by World Headache Society. This is an open-access article under the CC BY license (https://creativecommons.org/licenses/by/4.0/)


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